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Awaiting moderation 14 Article

Isophan e insulins used in young people: humulin, astraphane and others

        ISOPHAN E INSULINS USED IN YOUNG PEOPLE: HUMULIN, ASTRAPHANE AND OTHERS

Humulin NPH (Isophane Insulin NPH)
Humulin NPH has a moderately slow action.
This is a Human Isophane. Humulin NPH may start to have its effect within two hours of the injection (sometimes even before) and has-its maximum effect from between four to twelve hours. Activity fades rapidly after twenty four hours. For some children on small doses, it may provide good coverage of insulin through the whole day, but many children need a small addition of quick acting insulin (Humulin R) to the Humulin NPH to cover the early part of the day. The proportion of quick acting insulin to Humulin NPH will usually be about one to four, but this varies according to how a child responds to the insulin. For many children, the effect of Humulin NPH is not strong enough through the night and it may be necessary to give an evening injection as well.
A hypoglycemic reaction due to Humulin NPH given before breakfast is likely to occur in the late afternoon, but may occur during the night.

Actraphane (Isophane and neutral insulin mixed)
Actraphane is a mixture of Protaphane (70%) and Actrapid (30%). It is mixed as a convenience for those people who may need both a quick and slow acting insulin but who might have difficulties in mixing the two insulins in the syringe themselves.
Its effect may start in one hour and it has a maximum effect from four to fifteen hours with a fading of activity from then to twenty-four hours.
A hypoglycemic reaction due to Actraphane given before breakfast may occur during the late morning or afternoon.

Mixtard 30:70 (Isophane and neutral insulin mixed)
Mixtard has a combined fast and moderately slow action.
Mixtard is a mixture of Insulatard (70%) and Velosulin (30%). It is mixed as a convenience for those people who may need both a quick and slow acting insulin but who might have difficulties in mixing the two insulins in the syringe themselves. It has a start effect in one hour and a maximum effect from four to eight hours with a fading of activity from then to twenty-four
hours.
A hypoglycemic reaction due to Mixtard given before breakfast may occur during the late morning or afternoon.

Mixtard 50:50 (Isophane and neutral insulin mixed)
Initard has a combined fast and moderately slow action.
Initard is a mixture of Insulatard (50%) and Velosulin (50%). It is mixed as a convenience for those people who may need both a quick and slow acting insulin but who might have difficulties in mixing the two insulins in the syringe themselves. Its effect may start in one hour and it has a maximum effect from four to eight hours with a fading of activity from then to twenty-four hours.
A hypoglycemic reaction due to Initard given before breakfast may occur during the late morning or afternoon.

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